Journal: | Brazilian journal of physics |
Database: | PERIÓDICA |
System number: | 000403111 |
ISSN: | 0103-9733 |
Authors: | Oliveira, Adriano Marim de1 Oliveira, Pedro Carlos de1 Santos, Amilton Martins dos1 Zanin, Maria Helena Ambrosio2 Re, Maria Ines2 |
Institutions: | 1Universidade de Sao Paulo, Escola de Engenharia de Lorena, Lorena, Sao Paulo. Brasil 2Instituto de Pesquisas Tecnologicas do Estado de Sao Paulo, Sao Paulo. Brasil |
Year: | 2009 |
Season: | Abr |
Volumen: | 39 |
Number: | 1A |
Pages: | 217-222 |
Country: | Brasil |
Language: | Inglés |
Document type: | Artículo |
Approach: | Analítico |
English abstract | A new kind of thermo-responsive particles were prepared by the self-assembly technique, comprising poly(hydroxyvalerate-co-hydroxybutirate)-b-poly(N-isopropylacrylamide)/ (PHBHV-b-PNIPAAm) block copolymers. The hydrophilic part PNIPAAm was synthesized by Reversible Addition- Fragmentation chain Transfer (RAFT) polymerization. Particles with core-shell morphology were obtained with hydrophilic outer shells and hydrophobic inner cores. Dexametasone acetate (DexAc) was used as a model drug with an encapsulation efficiency of 77%. The release of DexAc in aqueous solution was strongly dependent on temperature, suggesting that PHBHV-b-PNIPAAm particles can be used as a thermo-responsive carrier material with external control in a drug release system |
Disciplines: | Química, Ingeniería |
Keyword: | Química de polímeros, Ingeniería de materiales, Nanopartículas |
Keyword: | Chemistry, Engineering, Polymer chemistry, Materials engineering, Nanoparticles |
Full text: | Texto completo (Ver PDF) |