| Revista: | Brazilian journal of physics |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000403111 |
| ISSN: | 0103-9733 |
| Autores: | Oliveira, Adriano Marim de1 Oliveira, Pedro Carlos de1 Santos, Amilton Martins dos1 Zanin, Maria Helena Ambrosio2 Re, Maria Ines2 |
| Instituciones: | 1Universidade de Sao Paulo, Escola de Engenharia de Lorena, Lorena, Sao Paulo. Brasil 2Instituto de Pesquisas Tecnologicas do Estado de Sao Paulo, Sao Paulo. Brasil |
| Año: | 2009 |
| Periodo: | Abr |
| Volumen: | 39 |
| Número: | 1A |
| Paginación: | 217-222 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | A new kind of thermo-responsive particles were prepared by the self-assembly technique, comprising poly(hydroxyvalerate-co-hydroxybutirate)-b-poly(N-isopropylacrylamide)/ (PHBHV-b-PNIPAAm) block copolymers. The hydrophilic part PNIPAAm was synthesized by Reversible Addition- Fragmentation chain Transfer (RAFT) polymerization. Particles with core-shell morphology were obtained with hydrophilic outer shells and hydrophobic inner cores. Dexametasone acetate (DexAc) was used as a model drug with an encapsulation efficiency of 77%. The release of DexAc in aqueous solution was strongly dependent on temperature, suggesting that PHBHV-b-PNIPAAm particles can be used as a thermo-responsive carrier material with external control in a drug release system |
| Disciplinas: | Química, Ingeniería |
| Palabras clave: | Química de polímeros, Ingeniería de materiales, Nanopartículas |
| Keyword: | Chemistry, Engineering, Polymer chemistry, Materials engineering, Nanoparticles |
| Texto completo: | Texto completo (Ver PDF) |
