Journal: | Brazilian journal of physics |
Database: | PERIÓDICA |
System number: | 000403112 |
ISSN: | 0103-9733 |
Authors: | Martins, P.S1 Ribeiro, R.R1 Bahia, A.P.C1 Neto, R.L.M1 Frezard, F1 Pimenta, A.M.C1 Melo, A.L1 Moyec, L. Le2 Demicheli, C3 |
Institutions: | 1Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil 2Universite de Paris XIII (Paris-Nord), París. Francia 3Universidade Federal de Minas Gerais, Instituto de Ciencias Exatas, Belo Horizonte, Minas Gerais. Brasil |
Year: | 2009 |
Season: | Abr |
Volumen: | 39 |
Number: | 1A |
Pages: | 223-225 |
Country: | Brasil |
Language: | Inglés |
Document type: | Artículo |
Approach: | Analítico |
English abstract | β-cyclodextrin (β-CD) is widely used as a component of pharmaceutical formulations, classically to improve the solubility and oral bioavailability of poorly water-soluble drugs through formation of drug/β-CD inclusion complexes. Unexpectedly, the association of the highly water-soluble drug meglumine antimoniate (MA) with β-CD turned this antimonial compound orally-active in a murine model of leishmaniasis. To get insight into the mechanisms responsible for the enhanced oral efficacy of MA, the MA/β-CD composition was characterized physicochemically, using thermogravimetry, circular dichroism, mass spectrometry (ESI-MS), osmometry and photon correlation spectroscopy. The freeze-dried MA/β-CD was found to form nanoassemblies in water, as a result of multiple non-inclusion interactions between MA and β-CD, which behave as a sustained release system of the MA drug |
Disciplines: | Química |
Keyword: | Fisicoquímica y química teórica, Química farmacéutica, Ciclodextrina |
Keyword: | Chemistry, Medicinal chemistry, Physical and theoretical chemistry, Cyclodextrin |
Full text: | Texto completo (Ver PDF) |