Physicochemical Characterization of Orally-Active Meglumine Antimoniate/Beta-Cyclodextrin Nanoassemblies: Non-Inclusion Interactions and Sustained Drug Release Properties
Título del documento: Physicochemical Characterization of Orally-Active Meglumine Antimoniate/Beta-Cyclodextrin Nanoassemblies: Non-Inclusion Interactions and Sustained Drug Release Properties
Revista: Brazilian journal of physics
Base de datos: PERIÓDICA
Número de sistema: 000403112
ISSN: 0103-9733
Autors: 1
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Institucions: 1Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil
2Universite de Paris XIII (Paris-Nord), París. Francia
3Universidade Federal de Minas Gerais, Instituto de Ciencias Exatas, Belo Horizonte, Minas Gerais. Brasil
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Període: Abr
Volum: 39
Número: 1A
Paginació: 223-225
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico
Resumen en inglés β-cyclodextrin (β-CD) is widely used as a component of pharmaceutical formulations, classically to improve the solubility and oral bioavailability of poorly water-soluble drugs through formation of drug/β-CD inclusion complexes. Unexpectedly, the association of the highly water-soluble drug meglumine antimoniate (MA) with β-CD turned this antimonial compound orally-active in a murine model of leishmaniasis. To get insight into the mechanisms responsible for the enhanced oral efficacy of MA, the MA/β-CD composition was characterized physicochemically, using thermogravimetry, circular dichroism, mass spectrometry (ESI-MS), osmometry and photon correlation spectroscopy. The freeze-dried MA/β-CD was found to form nanoassemblies in water, as a result of multiple non-inclusion interactions between MA and β-CD, which behave as a sustained release system of the MA drug
Disciplines Química
Paraules clau: Fisicoquímica y química teórica,
Química farmacéutica,
Ciclodextrina
Keyword: Chemistry,
Medicinal chemistry,
Physical and theoretical chemistry,
Cyclodextrin
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