Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes
Document title: Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451549
ISSN: 1984-8250
Authors: 1
2
3
Institutions: 1Jouf University, College of Science, Sakakah, Al-Jouf Province. Arabia Saudita
2University of Glasgow, Institute of Infection, Immunity and Inflammation, Glasgow, Lanark. Reino Unido
3Jouf University, College of Pharmacy, Sakakah, Al-Jouf Province. Arabia Saudita
Year:
Volumen: 57
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract In the present study a series of 34 synthetic ligustrazine-containing α, β-Unsaturated carbonyl-based compounds and oximes, recognized as anticancer compounds were assessed against protozoa of the Trypanosoma and Leishmania species. Ligustrazine, chemically known as tetramethylpyrazine (TMP), was selected as the core moiety for the synthesis of α, β-Unsaturated carbonyl-based compounds and these compounds were selected as precursors for the synthesis of new oximes. Some derivates, including 5f and 6i, showed multiple activities against all tested strains. In particular compounds 5f and 8o are the most potent and they are, therefore, potential candidates for trypanosomiasis and leishmaniasis
Disciplines: Química
Keyword: Química farmacéutica,
Antiparasitarios,
Ligustrazina,
Síntesis orgánica,
Trypanosoma,
Leishmania
Keyword: Medicinal chemistry,
Antiparasitic agents,
Ligustrazine,
Organic synthesis,
Trypanosoma,
Leishmania
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