| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451549 |
| ISSN: | 1984-8250 |
| Autores: | Alkhaldi, Abdulsalam A.M1 Koning, Harry P. de2 Bukhari, Syed Nasir Abbas3 |
| Instituciones: | 1Jouf University, College of Science, Sakakah, Al-Jouf Province. Arabia Saudita 2University of Glasgow, Institute of Infection, Immunity and Inflammation, Glasgow, Lanark. Reino Unido 3Jouf University, College of Pharmacy, Sakakah, Al-Jouf Province. Arabia Saudita |
| Año: | 2021 |
| Volumen: | 57 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | In the present study a series of 34 synthetic ligustrazine-containing α, β-Unsaturated carbonyl-based compounds and oximes, recognized as anticancer compounds were assessed against protozoa of the Trypanosoma and Leishmania species. Ligustrazine, chemically known as tetramethylpyrazine (TMP), was selected as the core moiety for the synthesis of α, β-Unsaturated carbonyl-based compounds and these compounds were selected as precursors for the synthesis of new oximes. Some derivates, including 5f and 6i, showed multiple activities against all tested strains. In particular compounds 5f and 8o are the most potent and they are, therefore, potential candidates for trypanosomiasis and leishmaniasis |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Antiparasitarios, Ligustrazina, Síntesis orgánica, Trypanosoma, Leishmania |
| Keyword: | Medicinal chemistry, Antiparasitic agents, Ligustrazine, Organic synthesis, Trypanosoma, Leishmania |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
