Journal: | Brazilian Journal of Pharmaceutical Sciences |
Database: | PERIÓDICA |
System number: | 000452155 |
ISSN: | 1984-8250 |
Authors: | Korashy, Mohamed A.R1 Gawad, Sherif A. Abdel2 Hassan, Nagiba Y3 AbdelKawy, M4 |
Institutions: | 1Pharmaoverseas Company, Quality Department, Alejandría. Egipto 2Prince Sattam Bin Abdul-Aziz University, College of Pharmacy, Alkharj. Arabia Saudita 3Cairo University, Faculty of Pharmacy, El Cairo. Egipto 4Future University, Faculty of Pharmaceutical Sciences, Al Tagamoa El Khames, Cairo. Egipto |
Year: | 2022 |
Volumen: | 58 |
Country: | Brasil |
Language: | Inglés |
Document type: | Artículo |
Approach: | Experimental, aplicado |
English abstract | Two sensitive and selective methods were developed for the simultaneous determination of four commonly used non-steroidal anti-inflammatory drugs (NSAIDs), namely; paracetamol (PCM), diclofenac sodium (DCF), ibuprofen (IBP), and indomethacin (IND) in wastewater effluents. The first method used HPLC for the determination of the studied drugs using a mobile phase consisting of phosphate buffer (pH 3.0) and acetonitrile at a flow rate of 1 mL/min. in gradient elution mode and detection at 220 nm. The separation process was performed on BDS Hypersil Cyano column (250 x 4.6 mm, 5 μm). The second method was a TLC-densitometric one which was performed using n-Hexane: ethyl acetate: acetic acid in the ratio (6:3.5:0.5) as a developing system. The proposed chromatographic methods were successfully applied for the selective determination of the four studied drugs in simulated and real pharmaceutical wastewater samples after their solid-phase extraction |
Disciplines: | Química |
Keyword: | Química farmacéutica, Química analítica, Antiinflamatorios no esteroideos, Residuos farmacéuticos, Cromatografía líquida de alta resolución (HPLC), Aguas residuales |
Keyword: | Medicinal chemistry, Analytical chemistry, Non steroidal antinflammatory drugs, Pharmaceutical wastes, High performance liquid chromatography (HPLC), Waste water |
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