Solid Phase Extraction and Simultaneous Chromatographic Quantification of some Non-steroidal Anti-inflammatory Drug Residues; an Application in Pharmaceutical Industrial Wastewater Effluent
Título del documento: Solid Phase Extraction and Simultaneous Chromatographic Quantification of some Non-steroidal Anti-inflammatory Drug Residues; an Application in Pharmaceutical Industrial Wastewater Effluent
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000452155
ISSN: 1984-8250
Autors: 1
2
3
4
Institucions: 1Pharmaoverseas Company, Quality Department, Alejandría. Egipto
2Prince Sattam Bin Abdul-Aziz University, College of Pharmacy, Alkharj. Arabia Saudita
3Cairo University, Faculty of Pharmacy, El Cairo. Egipto
4Future University, Faculty of Pharmaceutical Sciences, Al Tagamoa El Khames, Cairo. Egipto
Any:
Volum: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Two sensitive and selective methods were developed for the simultaneous determination of four commonly used non-steroidal anti-inflammatory drugs (NSAIDs), namely; paracetamol (PCM), diclofenac sodium (DCF), ibuprofen (IBP), and indomethacin (IND) in wastewater effluents. The first method used HPLC for the determination of the studied drugs using a mobile phase consisting of phosphate buffer (pH 3.0) and acetonitrile at a flow rate of 1 mL/min. in gradient elution mode and detection at 220 nm. The separation process was performed on BDS Hypersil Cyano column (250 x 4.6 mm, 5 μm). The second method was a TLC-densitometric one which was performed using n-Hexane: ethyl acetate: acetic acid in the ratio (6:3.5:0.5) as a developing system. The proposed chromatographic methods were successfully applied for the selective determination of the four studied drugs in simulated and real pharmaceutical wastewater samples after their solid-phase extraction
Disciplines Química
Paraules clau: Química farmacéutica,
Química analítica,
Antiinflamatorios no esteroideos,
Residuos farmacéuticos,
Cromatografía líquida de alta resolución (HPLC),
Aguas residuales
Keyword: Medicinal chemistry,
Analytical chemistry,
Non steroidal antinflammatory drugs,
Pharmaceutical wastes,
High performance liquid chromatography (HPLC),
Waste water
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