| Journal: | Brazilian journal of pharmaceutical sciences |
| Database: | PERIÓDICA |
| System number: | 000354327 |
| ISSN: | 1984-8250 |
| Authors: | Sayeed, Mohammed Aktar1 Habib, Razibul2 Rahman, Mominur1 Banna, Hasan Al1 Rana, Sohel3 |
| Institutions: | 1International Islamic University, Department of Pharmacy, Chittagong. Bangladesh 2East West University, Department of Pharmacy, Dhaka. Bangladesh 3Jahangirnagar University, Department of Pharmacy, Dhaka. Bangladesh |
| Year: | 2012 |
| Season: | Abr-Jun |
| Volumen: | 48 |
| Number: | 2 |
| Pages: | 211-216 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | The purpose of the present study was to investigate the interaction between ketotifen fumarate and anhydrous theophylline in aqueous media of various pH (1.2 and 6.8). Using Job’s continuous-variation analysis and Ardon’s spectrophotomeric measurement methods, the values of the stability constants of theophylline with ketotifen were determined at a fixed temperature (37 oC) at various pH. The stability constants, ranging between 5.66 and 9.92, were derived from Ardon’s plot, indicating that comparatively stable complexes had formed as a result of an interaction between the drugs. However, following the interaction of theophylline with ketotifen, stability constants were <1 at gastric pH (1.2) and intestinal pH (6.8). Concurrent administration of ketotifen and theophylline could result in the formation of a stable complex and this is likely to reduce the therapeutic activities of both drugs |
| Portuguese abstract | O objetivo do presente estudo foi investigar a interação entre o fumarato de cetotifeno e a teofilina anidra em meios aquosos com vários pH (1,2 e 6,8). Utilizando a análise da variação contínua de Job e os métodos de medida espectrofotométrica de Ardon, os valores das constantes de estabilidade da teofilina com o cetotifeno foram determinados em temperatura fixa (37 oC) em vários pH. As constantes de estabilidade, variando entre 5,66 e 9,92 derivaram-se a partir do delineamento de Ardon, indicando, comparativamente, que complexos estáveis se formaram como resultado da interação entre os fármacos. Entretanto, seguindo a interação da teofilina com o cetotifeno, as constantes de estabilidade foram <1, em pH gástrico (1,2) e intestinal (8,8). A administração concomitante de cetotifeno e teofilina poderia resultar na formação de complexo estável, o que reduz a atividade terapêutica de ambos os fármacos |
| Disciplines: | Química, Medicina |
| Keyword: | Química farmacéutica, Gastroenterología, Terapéutica y rehabilitación, Constantes de estabilidad, Método de Job, Método de Ardon, Cetotifeno, Teofilina |
| Keyword: | Chemistry, Medicine, Medicinal chemistry, Gastroenterology, Therapeutics and rehabilitation, Stability constants, Job method, Ardon method, Ketotifen, Theophylline |
| Full text: | Texto completo (Ver PDF) |
