Effects of pre-treatment with metoprolol and diltiazem on cerebral ischemia/reperfusion-induced injuries
Document title: Effects of pre-treatment with metoprolol and diltiazem on cerebral ischemia/reperfusion-induced injuries
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451818
ISSN: 1984-8250
Authors: 1
1
1
2
1
Institutions: 1Urmia University of Medical Sciences, School of Pharmacy, Urmia, Azerbaiyán. Irán
2Tabriz University of Medical Sciences, Faculty of Pharmacy, Tabriz. Irán
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Stroke is one of the most important health concerns worldwide. Calcium ions accumulation in the nerve cells and increase in the catecholamines level of the brain following cerebral ischemia/reperfusion (I/R) are accompanied by damaging effects. Therefore, the present study aimed to evaluate the effects of diltiazem, as a calcium channel blocker, and metoprolol, as a β-adrenoceptors antagonist, on I/R injury. In this study, 30 male Wistar rats were divided into control, I/R, metoprolol, diltiazem, and metoprolol plus diltiazem groups (n=6 in each). Metoprolol (1 mg/kg/day) and diltiazem (5 mg/kg/day) were injected intraperitoneally (i.p.) for 7 days before I/R induction. On day 8, the animals underwent ischemia by bilateral common carotid arteries occlusion for 20 min. Histopathological analysis showed a significant reduction in leukocyte infiltration in diltiazem, metoprolol, and diltiazem plus metoprolol treated rats compared with the I/R group (P<0.05, P<0.01, P<0.01, respectively). In addition, in all treated groups, myeloperoxidase activity and malondialdehyde levels in the brain tissue significantly declined compared with the I/R group (P<0.001). Furthermore, pre-treatment with diltiazem and metoprolol alone or in co-administration remarkably reduced infarct size following I/R (P<0.001). Overall, the results indicate the considerable neuroprotective effects of metoprolol and diltiazem in cerebral I/R
Disciplines: Medicina
Keyword: Sistema cardiovascular,
Farmacología,
Medicina experimental,
Isquemia cerebral,
Infarto cerebral,
Metoprolol,
Diltiazem,
Estrés oxidativo
Keyword: Cardiovascular system,
Pharmacology,
Experimental medicine,
Brain ischemia,
Brain infarction,
Metoprolol,
Diltiazem,
Oxidative stress
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