| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451818 |
| ISSN: | 1984-8250 |
| Autores: | Sadrhaghighi, Ghazaleh1 Abbaszadeh, Samin1 Babataheri, Shabnam1 Garjani, Alireza2 Soraya, Hamid1 |
| Instituciones: | 1Urmia University of Medical Sciences, School of Pharmacy, Urmia, Azerbaiyán. Irán 2Tabriz University of Medical Sciences, Faculty of Pharmacy, Tabriz. Irán |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Stroke is one of the most important health concerns worldwide. Calcium ions accumulation in the nerve cells and increase in the catecholamines level of the brain following cerebral ischemia/reperfusion (I/R) are accompanied by damaging effects. Therefore, the present study aimed to evaluate the effects of diltiazem, as a calcium channel blocker, and metoprolol, as a β-adrenoceptors antagonist, on I/R injury. In this study, 30 male Wistar rats were divided into control, I/R, metoprolol, diltiazem, and metoprolol plus diltiazem groups (n=6 in each). Metoprolol (1 mg/kg/day) and diltiazem (5 mg/kg/day) were injected intraperitoneally (i.p.) for 7 days before I/R induction. On day 8, the animals underwent ischemia by bilateral common carotid arteries occlusion for 20 min. Histopathological analysis showed a significant reduction in leukocyte infiltration in diltiazem, metoprolol, and diltiazem plus metoprolol treated rats compared with the I/R group (P<0.05, P<0.01, P<0.01, respectively). In addition, in all treated groups, myeloperoxidase activity and malondialdehyde levels in the brain tissue significantly declined compared with the I/R group (P<0.001). Furthermore, pre-treatment with diltiazem and metoprolol alone or in co-administration remarkably reduced infarct size following I/R (P<0.001). Overall, the results indicate the considerable neuroprotective effects of metoprolol and diltiazem in cerebral I/R |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Farmacología, Medicina experimental, Isquemia cerebral, Infarto cerebral, Metoprolol, Diltiazem, Estrés oxidativo |
| Keyword: | Cardiovascular system, Pharmacology, Experimental medicine, Brain ischemia, Brain infarction, Metoprolol, Diltiazem, Oxidative stress |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
