| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452195 |
| ISSN: | 1984-8250 |
| Authors: | Nocchi, Samara Requena1 Ferreira, Lilian dos Anjos Oliveira1 Castro Hoshino, Lidiane Vizioli de3 Truiti, Maria da Conceição Torrado1 Natali, Maria Raquel Marçal4 Mello, João Carlos Palazzo de1 Baesso, Mauro Luciano3 Dias, Benedito Prado2 Nakamura, Celso Vataru2 Ueda Nakamura, Tânia2 |
| Institutions: | 1Universidade Estadual de Maringa, Departamento de Farmacia, Maringa, Parana. Brasil 2Universidade Estadual de Maringa, Departamento de Ciencias Basicas da Saude, Maringa, Parana. Brasil 3Universidade Estadual de Maringa, Departamento de Fisica, Maringa, Parana. Brasil 4Universidade Estadual de Maringa, Departamento de Ciencias Morfologicas, Maringa, Parana. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroethanolic extract (CHE) from Schinus terebinthifolia were developed. Skin irritation, cutaneous permeation, and in vivo therapeutic efficacy of the formulations were investigated. Treatment with the ointment formulations did not result in any signs of skin irritation while the emulsions increased the thickness of the epidermis in Swiss mice. The cutaneous permeation test indicated that the CHE incorporated in the formulations permeated through the skin layers and was present in the epidermis and dermis even 3 h after topical application. In vivo antiviral activity in BALB/c mice treated with the CHE ointments was better than those treated with the CHE emulsions and did not significantly differ from an acyclovir-treated group. Taken together, this suggests that the incorporation of CHE in the ointment may be a potential candidate for the alternative topical treatment of herpetic lesions |
| Disciplines: | Química, Medicina |
| Keyword: | Farmacología, Infecciones virales, Herpes simple, Irritación cutánea, Plantas medicinales, Formulaciones tópicas, Schinus terebinthifolia, Anacardiaceae |
| Keyword: | Pharmacology, Viral infections, Herpes simplex, Skin irritation, Medicinal plants, Topical formulations, Schinus terebinthifolia, Anacardiaceae |
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