Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection



Título del documento: Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000452195
ISSN: 1984-8250
Autores: 1
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Instituciones: 1Universidade Estadual de Maringa, Departamento de Farmacia, Maringa, Parana. Brasil
2Universidade Estadual de Maringa, Departamento de Ciencias Basicas da Saude, Maringa, Parana. Brasil
3Universidade Estadual de Maringa, Departamento de Fisica, Maringa, Parana. Brasil
4Universidade Estadual de Maringa, Departamento de Ciencias Morfologicas, Maringa, Parana. Brasil
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroethanolic extract (CHE) from Schinus terebinthifolia were developed. Skin irritation, cutaneous permeation, and in vivo therapeutic efficacy of the formulations were investigated. Treatment with the ointment formulations did not result in any signs of skin irritation while the emulsions increased the thickness of the epidermis in Swiss mice. The cutaneous permeation test indicated that the CHE incorporated in the formulations permeated through the skin layers and was present in the epidermis and dermis even 3 h after topical application. In vivo antiviral activity in BALB/c mice treated with the CHE ointments was better than those treated with the CHE emulsions and did not significantly differ from an acyclovir-treated group. Taken together, this suggests that the incorporation of CHE in the ointment may be a potential candidate for the alternative topical treatment of herpetic lesions
Disciplinas: Química,
Medicina
Palabras clave: Farmacología,
Infecciones virales,
Herpes simple,
Irritación cutánea,
Plantas medicinales,
Formulaciones tópicas,
Schinus terebinthifolia,
Anacardiaceae
Keyword: Pharmacology,
Viral infections,
Herpes simplex,
Skin irritation,
Medicinal plants,
Topical formulations,
Schinus terebinthifolia,
Anacardiaceae
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