| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451766 |
| ISSN: | 1984-8250 |
| Authors: | Araújo, Aurigena Antunes de1 Silva, Edna Maria4 Mafra, Cristiane Assunção da Costa Cunha1 Costa, Íris do Céu Clara4 Barbalho, Amanda Lanna Andrade4 Matos, Iolanda Augusta Fernandes de4 Santos, Matheus Araujo dos4 Lopes, Maria Luiza Diniz de Sousa4 Medeiros, Caroline Addison Carvalho Xavier de3 Soares, Luiz Alberto Lira5 Machado, Janaina Carla Barbosa5 Ferreira, Magda Rhayanny Assunção5 Araújo, Raimundo Fernandes de6 Nascimento, Rubens Maribondo do1 Guerra, Gerlane Coelho Bernardo2 |
| Institutions: | 1Universidade Federal do Rio Grande do Norte, Programa de Pos-Graduacao em Odontologia, Natal, Rio Grande do Norte. Brasil 2Universidade Federal do Rio Grande do Norte, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Natal, Rio Grande do Norte. Brasil 3Universidade Federal do Rio Grande do Norte, Departamento de Biofisica e Farmacologia, Natal, Rio Grande do Norte. Brasil 4Universidade Federal do Rio Grande do Norte, Departamento de Odontologia, Natal, Rio Grande do Norte. Brasil 5Universidade Federal de Pernambuco, Departamento de Ciencias Farmaceuticas, Recife, Pernambuco. Brasil 6Universidade Federal do Rio Grande do Norte, Programa de Pos graduacao em Biologia Funcional e Estrutural, Natal, Rio Grande do Norte. Brasil 7Universidade Federal do Rio Grande do Norte, Programa de Pos-Graduacao em Engenharia de Materiais, Natal, Rio Grande do Norte. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Curcumin, contained at Turmeric (Curcumalonga), can exert many beneficial pleiotropic activities in the gastrointestinal tract. This study evaluated the antioxidant and anti-inflammatory activity of C. longa on 5-fluorouracil (5-FU)-induced oral mucositis (OM) in hamsters. Phytochemical analysis of crude C. longa extract (CLE) was performed to detect the presence of curcumin by TLC and HPLC. Golden Syrian hamsters were orally pre-treated with CLE (5, 50, or 100mg/kg). Cheek pouch samples were subjected to macroscopic and histopathological evaluation. ELISA was performed to quantify the inflammatory cytokines IL-1β and TNF-α. Superoxide dismutase (SOD), glutathione (GSH) and malondialdehyde (MDA) levels were assessed by ultraviolet-visible spectroscopy analysis. Behavior analysis was conducted by the open field test. Curcumin content in the CLE was 0.55%m/m ± 0.0161 (2.84%). The group treated with 5mg/kg CLE showed healing evidence with macroscopic absence of ulceration (p<0.05) and microscopic aspect of re-epithelialization, discrete inflammatory infiltrate and absence of edema. Treatment with 5mg/kg CLE significantly increased GSH levels, and reduced MDA levels and SOD activity (p˂0.05), and decreased IL-1β (p˂0.05) and TNF-α (p˂0.01) levels. A significant reduction in walking distance, ambulation, speed, and rearing was observed for motor activity. Curcumin reduced oxidative stress, inflammation, and motor activity in hamsters with 5-FU-induced OM |
| Disciplines: | Química, Medicina |
| Keyword: | Odontología, Farmacología, Mucositis oral, Curcumina, Estrés oxidativo, Inflamación |
| Keyword: | Dentistry, Pharmacology, Oral mucositis, Curcumin, Oxidative stress, Inflammation |
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