| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452099 |
| ISSN: | 1984-8250 |
| Authors: | Evangelista, Fernanda Cristina Gontijo1 Ferrão, Aline Lúcia Menezes1 Duarte, Rita Carolina Figueiredo1 Gomes, Lorena Caixeta1 Alves, Luan Carlos Vieira1 Campos, Fernanda Magalhães Freire1 Braga, Tatiane Vieira1 Santiago, Marie Gabriele1 Araújo, Sergio Schusterschitz da Silva2 Carvalho, Maria das Graças1 Sabino, Adriano de Paula1 |
| Institutions: | 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Hospital das Clinicas, Belo Horizonte, Minas Gerais. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Chronic Lymphocytic Leukemia (CLL) has shown great biological heterogeneity, with a variable prognosis, and a short survival in some patients. In this light, the present study focused on the prognostic utility of circulating microparticles (MPs) and a Thrombin Generation (TG) Profile for thrombotic risk and disease progression in CLL patients. Circulating microparticles and TG were evaluated in 35 patients with CLL and 35 healthy individuals. For circulating microparticles, significant differences were observed among the following groups: MPs derived from endothelial cells (p = 0.002), B lymphocytes (p < 0.001), platelets (p = 0.003), and Tissue Factor MPs in monocytes (p < 0.001). In all cases, MP values were higher for the CLL group. When compared to the controls, CLL patients presented a decrease in TG, characterized by a reduced endogen thrombin potential (ETP) (p = 0.031). When the results were analyzed according to the Binet stage, as compared to the controls, the Binet B+C group also presented lower ETP values (p = 0.009). No significant differences were observed between the control and the Binet A groups or between the Binet A and the Binet B + C groups. Although hemostatic alterations may occur in patients with CLL, these parameters do not seem to be useful to indicate disease progression |
| Disciplines: | Medicina, Química |
| Keyword: | Hematología, Oncología, Leucemia linfocítica crónica, Trombina, Micropartículas |
| Keyword: | Hematology, Oncology, Chronic lymphocytic leukemia, Microparticles, Thrombin |
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