| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451745 |
| ISSN: | 1984-8250 |
| Authors: | Andrade, João Paulo Campos1 Alves, Osvaine Junior Alvarenga1 Costa, Marian Caroline1 Gimenez, Valéria Maria Melleiro1 Squarisi, Iara Silva1 Nicolella, Heloiza Diniz1 Pagotti, Mariana Cintra1 Tavares, Denise Crispim1 Cunha, Wilson Roberto1 Silva, Márcio Luís Andrade e1 Januario, Ana Helena1 Magalhães, Lizandra Guidi1 Pauletti, Patrícia Mendonça1 |
| Institutions: | 1Universidade de Franca, Centro de Pesquisa em Ciencias Exatas e Tecnologicas, Franca, Sao Paulo. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Adenocalymma axillarum (K.Schum.) L.G. Lohmann is a liana belonging to the family Bignoniaceae. In traditional medicine, the genus Adenocalymma is used to treat fever, skin ailments, and body, joint, and facial muscle pains, and it is also applied as cosmetic. Biological assays conducted with the A. axillarum crude leaf ethanol extract have indicated leishmanicidal activity and absence of cytotoxicity. This study aimed to analyze the A. axillarum leaf ethanol crude extract by high-performance liquid chromatography-high-resolution mass spectrometry- diode array detector (HPLC-HRMS-DAD) and to evaluate the leishmanicidal and cytotoxic activities of this crude extract, its fractions, and isolated compounds. HPLC-HRMS-DAD analysis of this extract revealed that it consisted mainly of flavonoids, with nine major compounds. Extract purification yielded 4-hydroxy-N-methylproline, 6-β-hydroxyipolamiide, quercetin-3-O-robinobioside, hyperin, isorhamnetin-3-O-robinobioside, and 3’-O-methylhyperin, which were identified by Nuclear Magnetic Resonance. The isolated compounds were inactive against Leishmania amazonensis promastigotes and human lung fibroblast cells |
| Disciplines: | Biología, Química |
| Keyword: | Angiospermas, Fitoquímica, Plantas medicinales, Flavonoles, Glucósidos iridoideos, Citotoxidad, Adenocalymma axillarum, Bignoniaceae |
| Keyword: | Angiosperms, Phytochemistry, Medicinal plants, Cytotoxicity, Flavonols, Iridoid glycosides, Adenocalymma axillarum, Bignoniaceae |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
