| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451713 |
| ISSN: | 1984-8250 |
| Authors: | Vasconcelos, Priscilla Guimarães Silva1 Alves, Érika Ponchet1 Maia, Carolina Medeiros de Almeida1 Brito, Arella Cristina Muniz1 Silva, Diego Romário2 Freires, Irlan Almeida3 Cavalcanti, Yuri Wanderley4 Rehder, Vera Lucia Garcia5 Ruiz, Ana Lúcia Tasca Gois5 Duarte, Marta Cristina Teixeira5 Rosalen, Pedro Luiz2 Godoy, Gustavo Pina1 Costa, Edja Maria Melo de Brito1 |
| Institutions: | 1Universidade Estadual da Paraiba, Departamento de Odontologia, Campina Grande, Paraiba. Brasil 2Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Piracicaba, Sao Paulo. Brasil 3University of Florida, College of Dentistry, Gainesville, Florida. Estados Unidos de América 4Universidade Federal da Paraiba, Departamento de Odontologia Clinica e Social, Joao Pessoa, Paraiba. Brasil 5Universidade Estadual de Campinas, Centro de Pesquisa Pluridisciplinar de Quimica Biologica e Agronomica, Paulinia, Sao Paulo. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Schinus terebinthifolia Raddi green fruits essential oil (EO) was evaluated regarding its phytochemical profile, antimicrobial and cytotoxic activities, and toxicity. Gas chromatography with mass spectrometry was applied to identify its constituents, thereafter the minimum inhibitory concentration, minimum bactericidal and fungicidal concentrations, and its antibiofilm activity were evaluated. The EO cytotoxicity was assessed in tumor and non-tumor human cells, and in vivo toxicity was evaluated in a Galleria mellonella model. The major constituents of S. terebinthifolia EO were alpha-phellandrene and beta-phellandrene. The EO had a weak activity against all strains of Candida albicans (MIC 1000μg/mL) and had no activity against non-albicans strains, bacteria, and C. albicans biofilm. Cytostatic activity against all tumor cell lines was shown. Additionally, cell viability remained at EO concentrations up to 62.5 μg/mL. At 16 mg/mL, 50% hemolysis was observed, and it had low toxicity in vivo. Overall, the S. terebinthifolia EO was characterized by low antimicrobial and antibiofilm activities, with no evidence of toxicity to human tumor and non-tumor cells |
| Disciplines: | Biología, Química |
| Keyword: | Fitoquímica, Angiospermas, Aceites esenciales, Actividad antimicrobiana, Pruebas de toxicidad, Schinus terebinthifolia, Anacardiaceae |
| Keyword: | Phytochemistry, Angiosperms, Essential oils, Antimicrobial activity, Toxicity tests, Schinus terebinthifolia, Anacardiaceae |
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