| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452181 |
| ISSN: | 1984-8250 |
| Authors: | Kurtul, Ekin1 Eryilmaz, Müjde1 Sarialtin, Sezen Yilmaz1 Tekin, Mehmet2 Acikara, Ozlem Bahadir1 Coban, Tülay1 |
| Institutions: | 1Ankara University, Faculty of Pharmacy, Ankara. Turquía 2Trakya University, Faculty of Pharmacy, Edirne. Turquía |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The aim of this study was to determine antimicrobial activities of Alchemilla mollis, Alchemilla persica as well as ellagic acid and miquelianin against Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans by using microbroth dilution method and anti-inflammatory activity by using human red blood cell (HRBC) membrane stabilization method. Microbroth dilution method was used to determine the antimicrobial activities. Extracts possessed activity having MIC values of 2.5-5-10mg/ mL, compounds possessed activity having MIC values of 1.25-2.5-4-5mg/mL. A.mollis aerial parts displayed the highest anti-inflammatory activity (IC50=1.22±0.07mg/mL). Ellagic acid and miquelianin were also determined as anti-inflammatory agents with 0.57±0.01mg/mL and 1.23±0.02mg/mL IC50 values, respectively. Total phenolic content and tannin content of the A.mollis and A.persica were determined as 357.00±75.80mg, 282.50±28.70mg PGE/g plant material and 18.02%, 18.63% respectively according to the method described by European Pharmacopoeia. Ellagic acid, miquelianin and catechin were analyzed by HPLC. The highest catechin content was detected in A.persica roots (6.69±0.05g/100g plant material). A.mollis aerial parts contain higher miquelianin (0.39±0.02g/plant material) and ellagic acid (1.56±0.01g/ plant material) than A.persica |
| Disciplines: | Biología, Química |
| Keyword: | Fitoquímica, Angiospermas, Compuestos bioactivos, Actividad antimicrobiana, Miquelianina, Acido elágico, Alchemilla mollis, Alchemilla persica, Rosaceae |
| Keyword: | Phytochemistry, Angiosperms, Bioactive compounds, Alchemilla mollis, Alchemilla persica, Rosaceae, Antimicrobial activity, Miquelianin, Ellagic acid |
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