| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451862 |
| ISSN: | 1984-8250 |
| Autores: | Parhi, Rabinarayan1 Sahoo, Suvendu Kumar2 Das, Anik2 |
| Instituciones: | 1Assam University, Susruta School of Medical and Paramedical Sciences, Silchar, Assam. India 2GITAM University, GITAM Institute of Pharmacy, Visakhapatnam, Andhra Pradesh. India |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The main aim of transdermal drug delivery (TDD) is to deliver a specific dose of drug across the skin and to reach systemic circulation at a controlled rate. On the other hand skin is the target for topical drug delivery. Mentioned drug delivery systems (DDS) have numerous advantages compared to oral and parenteral routes. Avoidance of first-pass metabolism, prevent drug degradation due to harsh environment of the stomach, allow controlled drug delivery, provide patient compliance, and pain-free administration are a few of them. To achieve all of them, a DDS with suitable polymer is the primary requisite. Based on the recent trends, natural polymers have been more popular in comparison to synthetic polymers because the former possesses favourable properties including nontoxic, biodegradable, biocompatible, low cost, sustainable and renewable resources. In this context polysaccharides, composed of chains of monosaccharides bound together by glycosidic bonds, have been successfully employed to augment drug delivery into and across the skin with various formulations such as gel, membrane, patches, nanoparticles, nanofibres, nanocomposite, and microneedles. In this chapter, various polysaccharides such as cellulose, chitosan, and their semisynthetic derivatives, alginate, pectin, carrageenan etc, were discussed with their diverse topical and TDD applications. In addition, various formulations based on polysaccharides and limitations of polysaccharides were also briefly discussed |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Liberación controlada, Liberación transdérmica, Polímeros naturales, Polisacáridos, Hidrogeles |
| Keyword: | Medicinal chemistry, Controlled delivery, Transdermal delivery, Polysaccharides, Natural polymers, Hydrogels |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
