| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451773 |
| ISSN: | 1984-8250 |
| Authors: | Galvao, José Lucas Ferreira Marques1 Rosa, Lyvia Layanne Silva1 Diniz, Hermes1 Silva, Daniele de Figueredo1 Nóbrega, Jefferson Rodrigues1 Cordeiro, Laísa Vilar1 Figueiredo, Pedro Thiago Ramalho de1 Andrade, Francisco Patricio de1 Oliveira, Abrahao Alves de2 Lima, Edeltrudes de Oliveira1 |
| Institutions: | 1Universidade Federal da Paraiba, Departamento de Ciencias Farmaceuticas, Joao Pessoa, Paraiba. Brasil 2Universidade Federal de Campina Grande, Patos, Paraiba. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Pseudomonas aeruginosa is an important nosocomial pathogen and its clinical importance is mainly related to nosocomial infections. Increased rates of bacterial resistance in recent years has led WHO to publish a global priority list to guide research and discovery of new antibiotics, where P. aeruginosa is among the group of bacteria for which there is a critical level of priority for new drugs to be discovered. In this context, isoeugenol appears as an interesting alternative and the objective of this study was to investigate its action against P. aeruginosa. Isoeugenol presented significant antibacterial activity, with minimum inhibitory concentration (MIC) of 64µg/mL and minimum bactericidal concentration (MBC) of 128µg/mL, and was considered bactericidal against this species. Molecular docking revealed interactions that suggest that isoeugenol may bind to the enzyme Penicillin-Binding Protein 3 and interfere with the bacterial cell wall synthesis process. This study reinforces the antibacterial potential of this compound and emphasizes that more studies are needed in order to better investigate its mechanism of antibacterial action |
| Disciplines: | Medicina, Química |
| Keyword: | Microbiología, Farmacología, Productos naturales, Isoeugenol, Actividad antibacteriana, Pseudomonas aeruginosa |
| Keyword: | Microbiology, Pharmacology, Natural products, Isoeugenol, Antibacterial activity, Pseudomonas aeruginosa |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
