Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives
Document title: Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives
Journal: Brazilian journal of pharmaceutical sciences
Database: PERIÓDICA
System number: 000372415
ISSN: 1984-8250
Authors: 1
2
2
Institutions: 1GRD (P.G) Institute of Management and Technology, Department of Pharmacy, Dehra Dun, Uttar Pradesh. India
2Kumaun University, Department of Pharmaceutical sciences, Bheemtal, Nainital. India
Year:
Season: Oct-Dic
Volumen: 49
Number: 4
Pages: 903-909
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema method for the evaluation of analgesic and anti-inflammatory activities, respectively. Results showed that compounds 4f, 4b, 4d, and 4e exhibited higher analgesic and anti-inflammatory activities than other remaining compounds. All title compounds (4a-f) were characterized by IR, NMR and Mass spectroscopy
Portuguese abstract Diversos derivados benzilideno/furfurilideno piridazin(2H)-3-ona 6-aril-4-substituídos (4a-f) foram sintetizados e avaliados como analgésicos e anti-inflamatórios em camundongos e ratos, respectivamente. Todos os compostos foram testados utilizando-se o método de placa quente de Eddy e o de edema de pata induzido por carragenana para a avaliação das atividades analgésica e anti-inflamatória, respectivamente. Os resultados mostraram que os compostos 4f, 4b, 4d e 4e exibiram atividade analgésica e anti-inflamatória mais alta do que os compostos restantes. Todos os compostos (4a-f) foram caracterizados por IV, RMN e espectrometria de massas
Disciplines: Química
Keyword: Química farmacéutica,
Analgésicos,
Antiinflamatorios,
Actividad biológica,
Bioensayos,
Piridazinona
Keyword: Chemistry,
Medicinal chemistry,
Analgesics,
Antiinflammatory agents,
Biological activity,
Bioassays,
Pyridazinone
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