Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives
Título del documento: Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives
Revista: Brazilian journal of pharmaceutical sciences
Base de datos: PERIÓDICA
Número de sistema: 000372415
ISSN: 1984-8250
Autors: 1
2
2
Institucions: 1GRD (P.G) Institute of Management and Technology, Department of Pharmacy, Dehra Dun, Uttar Pradesh. India
2Kumaun University, Department of Pharmaceutical sciences, Bheemtal, Nainital. India
Any:
Període: Oct-Dic
Volum: 49
Número: 4
Paginació: 903-909
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema method for the evaluation of analgesic and anti-inflammatory activities, respectively. Results showed that compounds 4f, 4b, 4d, and 4e exhibited higher analgesic and anti-inflammatory activities than other remaining compounds. All title compounds (4a-f) were characterized by IR, NMR and Mass spectroscopy
Resumen en portugués Diversos derivados benzilideno/furfurilideno piridazin(2H)-3-ona 6-aril-4-substituídos (4a-f) foram sintetizados e avaliados como analgésicos e anti-inflamatórios em camundongos e ratos, respectivamente. Todos os compostos foram testados utilizando-se o método de placa quente de Eddy e o de edema de pata induzido por carragenana para a avaliação das atividades analgésica e anti-inflamatória, respectivamente. Os resultados mostraram que os compostos 4f, 4b, 4d e 4e exibiram atividade analgésica e anti-inflamatória mais alta do que os compostos restantes. Todos os compostos (4a-f) foram caracterizados por IV, RMN e espectrometria de massas
Disciplines Química
Paraules clau: Química farmacéutica,
Analgésicos,
Antiinflamatorios,
Actividad biológica,
Bioensayos,
Piridazinona
Keyword: Chemistry,
Medicinal chemistry,
Analgesics,
Antiinflammatory agents,
Biological activity,
Bioassays,
Pyridazinone
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