An overview of preparation and characterization of solid binary system and its application on transdermal film with variation of plasticizers
Document title: An overview of preparation and characterization of solid binary system and its application on transdermal film with variation of plasticizers
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451789
ISSN: 1984-8250
Authors: 1
1
1
Institutions: 1Jadavpur University, Department of Pharmaceutical Technology, Calcuta, Bengala Occidental. India
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Chemotherapy induced nausea and vomiting (CINV) and post-operative nausea and vomiting (PONV) is a problem, often occurs in patient. In spite of high bioavailability, the demerits such as: hepatic first pass metabolism and invasive nature of oral and parenteral dosage forms can be avoided with anti-emetic therapy of transdermal device. The major objective of the present study is to modify the hydrochloride (HCl) form of Ondansetron (OND) to the base form followed by improvement of solubility and permeability of OND by employing solid dispersion (SD) loaded patches. Preformulation study, as observed, begins with an approach to enthuse solubility of OND by SD technique choosing different carriers. The choice of carriers was rationalized by phase solubility study. Several combinations of transdermal films were prepared with pure drug, carriers and SDs with plasticizer Ka values of OND-HPβCD binary system were found lower (54.43 to 187.57 M-1) than that of OND-PVP K-30 binary system (1156.77 to 12203.6 M-1). The drug content of SDs and patches were found satisfactory. Better permeation rate (236.48±3.66 µg/3.935 cm2) with promising flux enhancement (8.30 fold) was found with DBP loaded SD patch (P6*). Hence, enhancement of solubility and permeability of P6* ensures that it can successfully enhance the bioavailability
Disciplines: Química
Keyword: Química farmacéutica,
Liberación de fármacos,
Liberación transdérmica,
Quimioterapia,
Ondansetrón,
Complejos de inclusión,
Permeación,
Películas transdérmicas
Keyword: Medicinal chemistry,
Drug delivery,
Transdermal drug delivery,
Chemotherapy,
Ondansetron,
Inclusion complex,
Permeation,
Transdermal films
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