Acetylcholinesterase inhibition, antioxidant and identification of some chemical constituents of Phyllanthus atropurpureus cultivated in Egypt
Document title: Acetylcholinesterase inhibition, antioxidant and identification of some chemical constituents of Phyllanthus atropurpureus cultivated in Egypt
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000450974
ISSN: 1984-8250
Authors: 1
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Institutions: 1National Research Centre, Pharmaceutical and Drug Industries Research Division, Dokki, Giza. Egipto
Year:
Volumen: 55
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Investigation of the lipid constituents of the aerial parts of Phyllanthus atropurpureus resulted in isolation and identification of the fatty acid mixture which consists of eight acids with linolenic acid as major and the unsaponifiable fraction that contain a series of hydrocarbons, sterols, in addition to one triterpene (α-amyrin). The acetone insoluble fraction was found to contain two fatty alcohols and three n-hydrocabons in which the n-eicosane is the most abundant (44.16%). The flavonoidal constituents were isolated from ethyl acetate and butanol fractions which were identified as: luteolin-7-O-glucoside, kaempferol 3-O-(p-coumaroylglucoside), kaempferitrin, luteolin and kaempferol. Evaluation of different extracts as acetylcholinesterase inhibitors (AChI), established the chloroform fraction as a promising inhibitor of the enzyme. The antioxidant testing with DPPH radical revealed the potential of precipitate from MeOH extract as a radical scavenger
Disciplines: Química
Keyword: Fitoquímica,
Flavonoides,
Inhibición enzimática,
Acetilcolinesterasa,
Actividad antioxidante,
Phyllanthus atropurpureus,
Euphorbiaceae
Keyword: Phytochemistry,
Flavonoids,
Enzymatic inhibition,
Acetylcholinesterase,
Antioxidant activity,
Phyllanthus atropurpureus,
Euphorbiaceae
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