| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000450974 |
| ISSN: | 1984-8250 |
| Autores: | Abdallah, Walid Elsayed1 Elsayed, Wael Mohamady1 Hassan, Rasmia Ali1 Nazif, Naglaa Mohammed1 Ali, Mohammed Ibrahim1 Abdelshafeek, Khaled Abdelhady1 |
| Instituciones: | 1National Research Centre, Pharmaceutical and Drug Industries Research Division, Dokki, Giza. Egipto |
| Año: | 2019 |
| Volumen: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Investigation of the lipid constituents of the aerial parts of Phyllanthus atropurpureus resulted in isolation and identification of the fatty acid mixture which consists of eight acids with linolenic acid as major and the unsaponifiable fraction that contain a series of hydrocarbons, sterols, in addition to one triterpene (α-amyrin). The acetone insoluble fraction was found to contain two fatty alcohols and three n-hydrocabons in which the n-eicosane is the most abundant (44.16%). The flavonoidal constituents were isolated from ethyl acetate and butanol fractions which were identified as: luteolin-7-O-glucoside, kaempferol 3-O-(p-coumaroylglucoside), kaempferitrin, luteolin and kaempferol. Evaluation of different extracts as acetylcholinesterase inhibitors (AChI), established the chloroform fraction as a promising inhibitor of the enzyme. The antioxidant testing with DPPH radical revealed the potential of precipitate from MeOH extract as a radical scavenger |
| Disciplinas: | Química |
| Palabras clave: | Fitoquímica, Flavonoides, Inhibición enzimática, Acetilcolinesterasa, Actividad antioxidante, Phyllanthus atropurpureus, Euphorbiaceae |
| Keyword: | Phytochemistry, Flavonoids, Enzymatic inhibition, Acetylcholinesterase, Antioxidant activity, Phyllanthus atropurpureus, Euphorbiaceae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
