| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451234 |
| ISSN: | 1984-8250 |
| Authors: | Karimi, Maryam1 Karimian, Khashayar2 Heli, Hossein1 |
| Institutions: | 1Shiraz University of Medical Sciences, Nanomedicine and Nanobiology Research Center, Shiraz. Irán 2Arasto Pharmaceutical Chemicals Inc., Teherán. Irán |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively |
| Disciplines: | Química, Medicina |
| Keyword: | Química farmacéutica, Anticancerígenos, Nanoemulsiones, Imatinib, Biodisponibilidad, Cáncer, Mama |
| Keyword: | Medicinal chemistry, Anticancer drugs, Nanoemulsions, Imatinib, Bioavailability, Breast, Cancer |
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