| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451234 |
| ISSN: | 1984-8250 |
| Autores: | Karimi, Maryam1 Karimian, Khashayar2 Heli, Hossein1 |
| Instituciones: | 1Shiraz University of Medical Sciences, Nanomedicine and Nanobiology Research Center, Shiraz. Irán 2Arasto Pharmaceutical Chemicals Inc., Teherán. Irán |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively |
| Disciplinas: | Química, Medicina |
| Palabras clave: | Química farmacéutica, Anticancerígenos, Nanoemulsiones, Imatinib, Biodisponibilidad, Cáncer, Mama |
| Keyword: | Medicinal chemistry, Anticancer drugs, Nanoemulsions, Imatinib, Bioavailability, Breast, Cancer |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
