| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451867 |
| ISSN: | 1984-8250 |
| Authors: | Bernardo, Larissa Rodrigues1 Ferreira, Laércia Karla Diega Paiva1 Ferreira, Larissa Adilis Maria Paiva1 Vieira, Cosmo Isaías Duvirgens1 Alves, Adriano Francisco1 Figueiredo, Pedro Thiago Ramalho2 Piuvezam, Marcia Regina1 |
| Institutions: | 1Universidade Federal da Paraiba, Departamento de Fisiologia e Patologia, Joao Pessoa, Paraiba. Brasil 2Universidade Federal da Paraiba, Departamento de Ciencias Farmaceuticas, Joao Pessoa, Paraiba. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | The monoterpene 4-carvomenthenol (Carvo) is found in essential oils of plant. Here, we evaluate the Carvo oral pretreatment in acute inflammatory experimental models and in silico molecular docking. Mice pretreated with Carvo were challenged and submitted to the protocols: paw edema, peritonitis, scratching behavior and anaphylactic shock reaction. Besides, we used histamine H1 receptor, cyclooxygenases (COX-1 and COX-2) and phospholipase A2, as targets for molecular docking analysis. Carvo inhibited the carrageenan-induced paw edema and decreased the peritoneal influx of polymorphonuclear cells on carrageenan-challenged mice without interfering with the mononuclear cell influx. Moreover, Carvo diminished the histamine, PGE2 and compound 48/80 induced paw edematogenic effect. The monoterpene also diminished the mice scratching behavior and, surprisingly, avoided the animal death caused by compound 48/80 in 30 min. Through the docking analysis, Carvo showed favorable binding energy to the histamine H1 receptor. This study demonstrates that Carvo attenuated the allergic inflammatory process, decreasing edema, cell migration, activation of mast cells and the histamine release, probably due to interaction of Carvo with the histamine H1 receptor, ameliorating the itching and the anaphylactic shock reaction. Therefore, the results of this study indicate that Carvo has anti-inflammatory properties by reducing the histamine effects |
| Disciplines: | Biología, Química |
| Keyword: | Fitoquímica, Angiospermas, Aceites esenciales, Monoterpenos, 4-carvomentenol, Actividad antiinflamatoria, Hipersensibilidad, Fitomedicina |
| Keyword: | Phytochemistry, Angiosperms, Essential oils, Monoterpenes, 4-carvomenthenol, Anti-inflammatory activity, Hypersensitivity, Phytomedicine |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
