Antibacterial, antifungal and cytotoxic activities of eight Asteraceae and two Rubiaceae plants from colombian biodiversity



Document title: Antibacterial, antifungal and cytotoxic activities of eight Asteraceae and two Rubiaceae plants from colombian biodiversity
Journal: Brazilian journal of microbiology
Database: PERIÓDICA
System number: 000291217
ISSN: 1517-8382
Authors: 1


Institutions: 1Universidad Tecnológica de Pereira, Grupo de Biotecnología - Productos Naturales, Pereira, Risaralda. Colombia
Year:
Season: Oct-Dic
Volumen: 37
Number: 4
Pages: 566-570
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental
English abstract Thirty crude extracts of eight plants belonging to Asteraceae and two to Rubiaceae families collected at different places from the Regional Natural Park Ucumarí (RNPU), Colombia, were tested for their antibacterial activity against two Gram-positive and two Gram-negative bacteria and three fungi. Both the antibacterial and the antimycotic activities were tested by the agar well diffusion method. The cytotoxic activity on the same plant extracts was determined through the brine shrimp lethality bioassay. The extracts from the Asteraceae family were more bioactive against Bacillus subtilis and Staphylococcus aureus. The extracts of both families studied were bioactive against the fungi Candida albicans and Fusarium solani. In addition, the extracts of Asteraceae species displayed the greatest cytotoxic activities. However, the most important specie in this research was Gonzalagunia rosea Standl (Rubiaceae) because of the strong and moderate activities of the methanol and dichloromethane extracts against C. albicans and F. solani, respectively; as well as the strong cytotoxic activity of the methanol extract. None of these ten plants has previously been reported for their biological activities
Portuguese abstract Trinta extratos crus de oito plantas da família Asteraceae e a duas plantas da família Rubiaceae, coletadas em diferentes lugares do Parque Natural Regional Ucumarí (PNRU), Colombia, foram avaliadas quanto à atividade contra duas bactérias Gram-positivas, duas Gram-negativas e três fungos. As atividades antibacteriana e antimicótica foram determinadas pelo método de difusão em agar. A atividade citotóxica dos mesmos extratos foi determinada através do bioensaio de Artemia salina. Os extratos da família Asteraceae foram os mais bioativos contra Bacillus subtilis e Staphylococcus aureus. Os extratos de ambas famílias estudadas foram bioativos contra os fungos Candida albicans e Fusarium solani. Os extratos da família Asteraceae exibiram maior atividade citotóxica. A espécie mais importante desta pesquisa foi Gonzalagunia rosea Standl (Rubiaceae) devido à atividade intensa e moderada dos extratos de metanol e diclorometano contra F. solani e C. albicans, respectivamente, bem como a intensa atividade citotóxica do extrato metanólico. Não se encontraram estudos prévios acerca das atividades biológicas das dez plantas avaliadas nesse estudo
Disciplines: Química,
Biología
Keyword: Fitoquímica,
Química farmacéutica,
Angiospermas,
Método de difusión de agar,
Antibióticos,
Artemia salina,
Bioprospección,
Flora,
Colombia
Keyword: Chemistry,
Biology,
Medicinal chemistry,
Phytochemistry,
Angiosperms,
Agar well diffusion method,
Antimicrobial screening,
Artemia salina,
Bioprospection,
Flora,
Colombia
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