Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite
Document title: Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite
Journal: Brazilian journal of medical and biological research
Database: PERIÓDICA
System number: 000350351
ISSN: 0100-879X
Authors: 1
2
1
1
1
1
1
Institutions: 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Odontologia, Araraquara, Sao Paulo. Brasil
2Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias Farmaceuticas, Araraquara, Sao Paulo. Brasil
Year:
Season: May
Volumen: 40
Number: 5
Pages: 707-712
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to induce water intake. However, sodium appetite is also elicited by water deprivation. In this brief review, we stress the importance of the water-depletion and partial extracellular fluid-repletion protocol which permits the distinction between sodium appetite and thirst. Consistent enhancement or a de novo production of sodium intake induced by deactivation of inhibitory nuclei (e.g., lateral parabrachial nucleus) or hormones (oxytocin, atrial natriuretic peptide), in water-deprived, extracellular-dehydrated or, contrary to tradition, intracellular-dehydrated rats, suggests that sodium appetite and thirst share more mechanisms than previously thought. Water deprivation has physiological and health effects in humans that might be related to the salt craving shown by our species
Disciplines: Medicina
Keyword: Fisiología humana,
Neurología,
Privación de agua,
Deshidratación,
Apetito,
Sodio
Keyword: Medicine,
Human physiology,
Neurology,
Water deprivation,
Dehydration,
Appetite,
Sodium
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