Revista: | Brazilian journal of medical and biological research |
Base de datos: | PERIÓDICA |
Número de sistema: | 000350351 |
ISSN: | 0100-879X |
Autores: | De Luca-Junior, L.A1 Vendramini, R.C2 Pereira, D.T.B1 Colombari, D.A.S1 David, R.B1 Paula, P.M1 Menani, J.V1 |
Instituciones: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Odontologia, Araraquara, Sao Paulo. Brasil 2Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias Farmaceuticas, Araraquara, Sao Paulo. Brasil |
Año: | 2007 |
Periodo: | May |
Volumen: | 40 |
Número: | 5 |
Paginación: | 707-712 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to induce water intake. However, sodium appetite is also elicited by water deprivation. In this brief review, we stress the importance of the water-depletion and partial extracellular fluid-repletion protocol which permits the distinction between sodium appetite and thirst. Consistent enhancement or a de novo production of sodium intake induced by deactivation of inhibitory nuclei (e.g., lateral parabrachial nucleus) or hormones (oxytocin, atrial natriuretic peptide), in water-deprived, extracellular-dehydrated or, contrary to tradition, intracellular-dehydrated rats, suggests that sodium appetite and thirst share more mechanisms than previously thought. Water deprivation has physiological and health effects in humans that might be related to the salt craving shown by our species |
Disciplinas: | Medicina |
Palabras clave: | Fisiología humana, Neurología, Privación de agua, Deshidratación, Apetito, Sodio |
Keyword: | Medicine, Human physiology, Neurology, Water deprivation, Dehydration, Appetite, Sodium |
Texto completo: | Texto completo (Ver HTML) |