| Journal: | Brazilian journal of medical and biological research |
| Database: | PERIÓDICA |
| System number: | 000350958 |
| ISSN: | 0100-879X |
| Authors: | Goncalves, W.L.S1 Souza, F.M1 Conti, C.L1 Cirqueira, J.P1 Rocha, W.A1 Pires, J.G.P1 Barros, L.A.P1 Moyses, M.R1 |
| Institutions: | 1Universidade Federal do Espirito Santo, Centro de Ciencias da Saude, Vitoria, Espirito Santo. Brasil |
| Year: | 2007 |
| Season: | Jun |
| Volumen: | 40 |
| Number: | 6 |
| Pages: | 877-884 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | We determined the effects of helium-neon (He-Ne) laser irradiation on wound healing dynamics in mice treated with steroidal and non-steroidal anti-inflammatory agents. Male albino mice, 28-32 g, were randomized into 6 groups of 6 animals each: control (C), He-Ne laser (L), dexamethasone (D), D + L, celecoxib (X), and X + L. D and X were injected im at doses of 5 and 22 mg/kg, respectively, 24 h before the experiment. A 1-cm long surgical wound was made with a scalpel on the abdomens of the mice. Animals from groups L, D + L and X + L were exposed to 4 J (cm2)-1 day-1 of He-Ne laser for 12 s and were sacrificed on days 1, 2, or 3 after the procedure, when skin samples were taken for histological examination. A significant increase of collagen synthesis was observed in group L compared with C (168 ± 20 vs 63 ± 8 mm2). The basal cellularity values on day 1 were: C = 763 ± 47, L = 1116 ± 85, D = 376 ± 24, D + L = 698 ± 31, X = 453 ± 29, X + L = 639 ± 32 U/mm2. These data show that application of L increases while D and X decrease the inflammatory cellularity compared with C. They also show that L restores the diminished cellularity induced by the anti-inflammatory drugs. We suggest that He-Ne laser promotes collagen formation and restores the baseline cellularity after pharmacological inhibition, indicating new perspectives for laser therapy aiming to increase the healing process when anti-inflammatory drugs are used |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Traumatología, Terapéutica, Cicatrización, Laserterapia, Colágeno, Antiinflamatorios, Corticosteroides, Ciclooxigenasa |
| Keyword: | Medicine, Pharmacology, Traumatology, Therapeutics, Wound healing, Laser therapy, Collagen, Antiinflammatory agents, Corticosteroids, Cyclooxygenase |
| Full text: | Texto completo (Ver HTML) |
