nfluence of He-Ne laser therapy on the dynamics of wound healing in mice treated with anti-inflammatory drugs



Título del documento: nfluence of He-Ne laser therapy on the dynamics of wound healing in mice treated with anti-inflammatory drugs
Revista: Brazilian journal of medical and biological research
Base de datos: PERIÓDICA
Número de sistema: 000350958
ISSN: 0100-879X
Autores: 1
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Instituciones: 1Universidade Federal do Espirito Santo, Centro de Ciencias da Saude, Vitoria, Espirito Santo. Brasil
Año:
Periodo: Jun
Volumen: 40
Número: 6
Paginación: 877-884
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés We determined the effects of helium-neon (He-Ne) laser irradiation on wound healing dynamics in mice treated with steroidal and non-steroidal anti-inflammatory agents. Male albino mice, 28-32 g, were randomized into 6 groups of 6 animals each: control (C), He-Ne laser (L), dexamethasone (D), D + L, celecoxib (X), and X + L. D and X were injected im at doses of 5 and 22 mg/kg, respectively, 24 h before the experiment. A 1-cm long surgical wound was made with a scalpel on the abdomens of the mice. Animals from groups L, D + L and X + L were exposed to 4 J (cm2)-1 day-1 of He-Ne laser for 12 s and were sacrificed on days 1, 2, or 3 after the procedure, when skin samples were taken for histological examination. A significant increase of collagen synthesis was observed in group L compared with C (168 ± 20 vs 63 ± 8 mm2). The basal cellularity values on day 1 were: C = 763 ± 47, L = 1116 ± 85, D = 376 ± 24, D + L = 698 ± 31, X = 453 ± 29, X + L = 639 ± 32 U/mm2. These data show that application of L increases while D and X decrease the inflammatory cellularity compared with C. They also show that L restores the diminished cellularity induced by the anti-inflammatory drugs. We suggest that He-Ne laser promotes collagen formation and restores the baseline cellularity after pharmacological inhibition, indicating new perspectives for laser therapy aiming to increase the healing process when anti-inflammatory drugs are used
Disciplinas: Medicina
Palabras clave: Farmacología,
Traumatología,
Terapéutica,
Cicatrización,
Laserterapia,
Colágeno,
Antiinflamatorios,
Corticosteroides,
Ciclooxigenasa
Keyword: Medicine,
Pharmacology,
Traumatology,
Therapeutics,
Wound healing,
Laser therapy,
Collagen,
Antiinflammatory agents,
Corticosteroids,
Cyclooxygenase
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