| Journal: | Brazilian journal of medical and biological research |
| Database: | PERIÓDICA |
| System number: | 000350949 |
| ISSN: | 0100-879X |
| Authors: | Veiga, C.P1 Miczek, K.A2 Lucion, A.B1 Almeida, R.M.M. de3 |
| Institutions: | 1Universidade Federal do Rio Grande do Sul, Programa de Pos-Graduacao em Neurociencias, Porto Alegre, Rio Grande do Sul. Brasil 2Tufts University, Department of Psychology, Psychiatry, Pharmacology and Neuroscience, Boston, Massachusetts. Estados Unidos de América 3Universidade do Vale do Rio dos Sinos, Laboratorio de Neurociencias, Sao Leopoldo, Rio Grande do Sul. Brasil |
| Year: | 2007 |
| Season: | Jun |
| Volumen: | 40 |
| Number: | 6 |
| Pages: | 825-830 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 µg/0.2 µL, N = 8, and 1.0 µg/0.2 µL, N = 8) or CP-93,129 (1.0 µg/0.2 µL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation |
| Disciplines: | Biología |
| Keyword: | Fisiología animal, Mamíferos, Corteza prefrontal, Serotonina, Neurorreceptores, Agresividad, Ratas |
| Keyword: | Biology, Animal physiology, Mammals, Prefrontal cortex, Serotonin, Neuroreceptors, Aggressivity, Rats |
| Full text: | Texto completo (Ver HTML) |
