Comparison of pre- versus post-incision administration of intraplantar indomethacin and MK886 in a rat model of postoperative pain
Título del documento: Comparison of pre- versus post-incision administration of intraplantar indomethacin and MK886 in a rat model of postoperative pain
Revista: Brazilian journal of medical and biological research
Base de datos: PERIÓDICA
Número de sistema: 000351247
ISSN: 0100-879X
Autores: 1
1
Instituciones: 1Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
Año:
Periodo: Ago
Volumen: 40
Número: 8
Paginación: 1141-1147
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés The amplification of pain long after the initial stimulus may be avoided if the treatment of pain is introduced before its initiation. However, conflicting evidence exists about the efficacy of such preemptive analgesia for the management of postoperative pain. This study compares the efficacy of intraplantar administration of indomethacin (a non-selective inhibitor of cyclooxygenase) and MK886 (an inhibitor of 5-lipoxygenase-activating protein), separately or in combination to produce preemptive analgesia in a model of surgical incisional pain in male Wistar rats. All incised rats (5 to 6 rats per group) had allodynia at 2, 6, and 24 h after surgery as evaluated using von Frey filaments. MK886, but not indomethacin (50 to 200 µg/paw), reduced the allodynia when injected either 1 h before or 1 h after surgery. The effect of preoperative MK886 (160 µg/paw) against incisional allodynia had a magnitude apparently similar to that produced by postoperative MK886. Pre-, but not postoperative MK886 (80 µg/paw) reduced the allodynia but the effect was seen only at 6 h after surgery. In contrast, MK886 (40 µg/paw) intensified the allodynia observed 2 h after the incision either injected before or after surgery. MK886 or indomethacin alone did not provide preemptive analgesia in the model of incisional pain. In contrast, the combination of MK886 with indomethacin reduced the allodynia more effectively when used before than after surgery, thus fulfilling the criteria for preemptive analgesia. In conclusion, preoperative inhibition of the local generation of both prostaglandins and leukotrienes by surgical incision may be an alternative to provide preemptive analgesia
Disciplinas: Medicina
Palabras clave: Cirugía,
Farmacología,
Analgesia,
Dolor posoperatorio,
Indometacina
Keyword: Medicine,
Pharmacology,
Surgery,
Analgesia,
Postoperative pain,
Indomethacin
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