| Revista: | Brazilian journal of chemical engineering |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000308968 |
| ISSN: | 0104-6632 |
| Autores: | Maia, J.L1 Santana, M.H.A Re, M.I2 |
| Instituciones: | 1Universidade Estadual de Campinas, Faculdade de Engenharia Quimica, Campinas, Sao Paulo. Brasil 2Instituto de Pesquisas Tecnologicas do Estado de Sao Paulo, Divisao de Quimica, Sao Paulo. Brasil |
| Año: | 2004 |
| Periodo: | Ene |
| Volumen: | 21 |
| Número: | 1 |
| Paginación: | 01-12 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Unloaded microspheres were prepared from polyhydroxybutyrate (PHB) and polyhydroxybutyrate-co-valerate (PHB-HV) polymers using an oil-in-water emulsion solvent evaporation method. The study was conducted to evaluate how the polymer and some process parameters affect properties of the final microspheres such as particle size, superficial area, zeta potential, surface morphology and microsphere degradation. The variables included surfactant concentration in the emulsion water phase and solvent composition. From the results, it was found that the parameters affecting microsphere size the most were surfactant concentration in the emulsion water phase and solvent composition. Properties such as zeta potential, surface area and surface morphology remained pratically unchanged over the range of the processing conditions studied here |
| Disciplinas: | Química |
| Palabras clave: | Química de polímeros, Química farmacéutica, Microencapsulación, Emulsificación, Poli-hidroxibutirato-hidroxivalerato, Sistemas de liberación de fármacos |
| Keyword: | Chemistry, Medicinal chemistry, Polymer chemistry, Microencapsulation, Emulsification, Poly-hydroxybutirate-hydroxyvalerate, Drug delivery systems |
| Texto completo: | Texto completo (Ver HTML) |
