Spray-dried chitosan microspheres cross-linked with d, l-glyceraldehyde as a potential drug delivery system: preparation and characterization
Document title: Spray-dried chitosan microspheres cross-linked with d, l-glyceraldehyde as a potential drug delivery system: preparation and characterization
Journal: Brazilian journal of chemical engineering
Database: PERIÓDICA
System number: 000308985
ISSN: 0104-6632
Authors: 1

2
Institutions: 1Universidade Estadual de Campinas, Faculdade de Engenharia Quimica, Campinas, Sao Paulo. Brasil
2Instituto de Pesquisas Tecnologicas do Estado de Sao Paulo, Divisao de Quimica, Sao Paulo. Brasil
Year:
Season: Sep
Volumen: 22
Number: 3
Pages: 353-360
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Chitosan microspheres of a small particle size and with good sphericity were prepared by a spray-drying method followed by treatment with a cross-linking agent. Owing to restrictions on the use of cross-linked chitosan microspheres in the pharmaceutical field, d,l-glyceraldehyde, a biocompatible reatant was used. The parameters studied affecting extent of cross-linking were cross-linking time and concentration of the cross-linking agent. Glutaraldehyde, the aldehyde most frequently employed as chemical cross-linking agent for proteins, was also used as a control. The cross-linked spray-dried chitosan microspheres were analyzed with respect to their morphological aspects, particle size, zeta potential and water uptake capacity. It was found that an increase either in d,l-glyceraldehyde concentration or in duration of cross-linking caused a decrease in both the swelling capacity and the zeta potential of the chitosan microspheres. Compared to glutaraldehyde, d,l-glyceraldehyde appears to be a good cross-linking agent for chitosan microspheres with the advantage that it is nontoxic
Disciplines: Química
Keyword: Química farmacéutica,
Gliceraldehído,
Quitosana,
Microesferas,
Secado por aspersión,
Sistemas de liberación de fármacos
Keyword: Chemistry,
Medicinal chemistry,
Glyceraldehyde,
Chitosan,
Microspheres,
Spray drying,
Drug delivery systems
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