Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
Document title: Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
Journal: Brazilian archives of biology and technology
Database: PERIÓDICA
System number: 000387740
ISSN: 1516-8913
Authors: 1
2
2
Institutions: 1Anadolu University, Science Faculty, Eskisehir. Turquía
2Gazi University, Vocational High School of Health Services, Ankara. Turquía
Year:
Season: Jul-Ago
Volumen: 58
Number: 4
Pages: 587-594
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental
English abstract The aim of the present study was to elucidate the possible protective role of vitamin E and / or sodium selenite on mercuric chloride-induced oxidative stress and histopathological changes in the lung tissue of the rats. Adult male albino Wistar rats were exposed to mercuric chloride (1.0 mg/kg day) for four weeks. Treatment with mercuric chloride led to oxidative stress by enhancing MDA level and also decreasing superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx) and glutathione S transferaz (GST) activities. However, mercuric chloride exposure resulted in histopathological changes in the lung tissue in the rats. MDA level and SOD, CAT GPx and GST activities and histopathological changes modulated in concomitantly supplementation of vitamin E (100 mg/kg day) and /or sodium selenite (0.25 mg/kg day) to mercuric chloride-treated groups
Disciplines: Medicina
Keyword: Farmacología,
Medicina experimental,
Toxicología,
Cloruro de mercurio,
Selenito de sodio,
Toxicidad,
Pulmones,
Estrés oxidativo,
Efecto protector,
Vitamina E,
Histopatología
Keyword: Medicine,
Experimental medicine,
Pharmacology,
Toxicology,
Mercuric chloride,
Sodium selenite,
Lungs,
Toxicity,
Oxidative stress,
Protective effect,
Vitamin E,
Histopathology
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