Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
Título del documento: Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats
Revista: Brazilian archives of biology and technology
Base de datos: PERIÓDICA
Número de sistema: 000387740
ISSN: 1516-8913
Autors: 1
2
2
Institucions: 1Anadolu University, Science Faculty, Eskisehir. Turquía
2Gazi University, Vocational High School of Health Services, Ankara. Turquía
Any:
Període: Jul-Ago
Volum: 58
Número: 4
Paginació: 587-594
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental
Resumen en inglés The aim of the present study was to elucidate the possible protective role of vitamin E and / or sodium selenite on mercuric chloride-induced oxidative stress and histopathological changes in the lung tissue of the rats. Adult male albino Wistar rats were exposed to mercuric chloride (1.0 mg/kg day) for four weeks. Treatment with mercuric chloride led to oxidative stress by enhancing MDA level and also decreasing superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx) and glutathione S transferaz (GST) activities. However, mercuric chloride exposure resulted in histopathological changes in the lung tissue in the rats. MDA level and SOD, CAT GPx and GST activities and histopathological changes modulated in concomitantly supplementation of vitamin E (100 mg/kg day) and /or sodium selenite (0.25 mg/kg day) to mercuric chloride-treated groups
Disciplines Medicina
Paraules clau: Farmacología,
Medicina experimental,
Toxicología,
Cloruro de mercurio,
Selenito de sodio,
Toxicidad,
Pulmones,
Estrés oxidativo,
Efecto protector,
Vitamina E,
Histopatología
Keyword: Medicine,
Experimental medicine,
Pharmacology,
Toxicology,
Mercuric chloride,
Sodium selenite,
Lungs,
Toxicity,
Oxidative stress,
Protective effect,
Vitamin E,
Histopathology
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