Potential Use of Polysaccharides from the Brown Alga Undaria pinnatifida as Anticoagulants



Document title: Potential Use of Polysaccharides from the Brown Alga Undaria pinnatifida as Anticoagulants
Journal: Brazilian archives of biology and technology
Database: PERIÓDICA
System number: 000392772
ISSN: 1516-8913
Authors: 1
2
1
1
1
1
Institutions: 1University of Messina, Department of Biological and Environmental Sciences, Messina, Sicilia. Italia
2Universita Ca' Foscari, Department of Environmental Sciences, Informatics and Statistics, Venecia. Italia
Year:
Season: Sep-Oct
Volumen: 58
Number: 5
Pages: 798-804
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Undaria pinnatifida (U. pinnatifida) is a highly invasive species and has caused concern all over the world because it has invaded coasta l environments, has the potential to displace native species, significantly alters habitat for associated fauna, and disturbs navigation. Any attempt to eradicate it would be futile, owing to the elusive, microscopic gametophyte, and because the alga thriv es in sites rich in anthropic activities. Venice Lagoon is the largest Mediterranean transitional environment and the spot of the highest introduction of non - indigenous species, including U. pinnatifida , which is removed as a waste. We demonstrated that po lysaccharide extracts from U. pinnatifida have an anticoagulant effect on human blood in vitro and are not cytotoxic. The results obtained by PT (normal values 70 - 120%) and APTT (normal values 28 - 40s) assays were significantly prolonged by the polysacchar ide extracts of U. pinnatifida , therefore algal extracts are ideal candidates as antithrombotic agents
Disciplines: Química,
Biología
Keyword: Fitoquímica,
Algas,
Biología celular,
Extractos,
Anticoagulantes,
Citotoxicidad,
Sangre,
Polisacáridos,
Undaria pinnatifida
Keyword: Chemistry,
Biology,
Phytochemistry,
Algae,
Cell biology,
Extracts,
Anticoagulants,
Cytotoxicity,
Blood,
Polysaccharides,
Undaria pinnatifida
Full text: Texto completo (Ver PDF)