Potential Use of Polysaccharides from the Brown Alga Undaria pinnatifida as Anticoagulants



Título del documento: Potential Use of Polysaccharides from the Brown Alga Undaria pinnatifida as Anticoagulants
Revista: Brazilian archives of biology and technology
Base de datos: PERIÓDICA
Número de sistema: 000392772
ISSN: 1516-8913
Autors: 1
2
1
1
1
1
Institucions: 1University of Messina, Department of Biological and Environmental Sciences, Messina, Sicilia. Italia
2Universita Ca' Foscari, Department of Environmental Sciences, Informatics and Statistics, Venecia. Italia
Any:
Període: Sep-Oct
Volum: 58
Número: 5
Paginació: 798-804
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Undaria pinnatifida (U. pinnatifida) is a highly invasive species and has caused concern all over the world because it has invaded coasta l environments, has the potential to displace native species, significantly alters habitat for associated fauna, and disturbs navigation. Any attempt to eradicate it would be futile, owing to the elusive, microscopic gametophyte, and because the alga thriv es in sites rich in anthropic activities. Venice Lagoon is the largest Mediterranean transitional environment and the spot of the highest introduction of non - indigenous species, including U. pinnatifida , which is removed as a waste. We demonstrated that po lysaccharide extracts from U. pinnatifida have an anticoagulant effect on human blood in vitro and are not cytotoxic. The results obtained by PT (normal values 70 - 120%) and APTT (normal values 28 - 40s) assays were significantly prolonged by the polysacchar ide extracts of U. pinnatifida , therefore algal extracts are ideal candidates as antithrombotic agents
Disciplines Química,
Biología
Paraules clau: Fitoquímica,
Algas,
Biología celular,
Extractos,
Anticoagulantes,
Citotoxicidad,
Sangre,
Polisacáridos,
Undaria pinnatifida
Keyword: Chemistry,
Biology,
Phytochemistry,
Algae,
Cell biology,
Extracts,
Anticoagulants,
Cytotoxicity,
Blood,
Polysaccharides,
Undaria pinnatifida
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