| Journal: | Brazilian archives of biology and technology |
| Database: | PERIÓDICA |
| System number: | 000387722 |
| ISSN: | 1516-8913 |
| Authors: | Vitiello, Glauco Akelinghton Freire1 Guembarovski, Roberta Losi1 Oliveira, Carlos Eduardo Coral de1 Amarante, Marla Karine2 Perim, Aparecida de Lourdes2 Watanabe, Maria Angelica Ehara1 |
| Institutions: | 1Universidade Estadual de Londrina, Departamento de Ciencias Patologicas, Londrina, Parana. Brasil 2Universidade Estadual de Londrina, Departamento de Patologia, Analises Clínicas e Toxicologicas, Londrina, Parana. Brasil |
| Year: | 2015 |
| Season: | Jul-Ago |
| Volumen: | 58 |
| Number: | 4 |
| Pages: | 553-561 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Hematological malignancies (HM) are a group of neoplastic diseases that arise from hematologic cell lineages. Transforming growth factor beta 1 (TGFβ1) is shown to negatively regulate normal and malignant hematopoiesis and, in immunological context, to promote T cell exhaustion and generation of regulatory T cells, which are shown to be deleterious in cancer, by the induction of transcription factor FOXP3 expression. The present study aimed to evaluate TGFB1 exon-1 rs1800470 and FOXP3 intron-1 rs2232365 polymorphisms in relation to HM susceptibility. DNA was extracted from blood samples of 43 HM patients and 142 neoplasia-free individuals and polymorphisms were analyzed by allelic-specific PCR. Association analysis was assessed by the Odds Ratio (OR) with significance level of 5%. Regarding FOXP3 polymorphism, no significant differences were observed in genotype or allele distribution among the patients and controls. However, there was a positive association between TGFB1 TT genotype and HM susceptibility (OR = 4.07; CI95% = 1.94 - 8.52). In the combined analysis, a positive association was also observed for TGFB1 TT and FOXP3 GG genotypes (OR = 4.00; CI95% = 1.54 - 10.41) in relation to HM susceptibility. Our results indicated promising new markers to be further investigated in hematological malignancies |
| Disciplines: | Medicina |
| Keyword: | Hematología, Bioquímica, Enfermedades hematológicas, Factor de crecimiento transformante, Citocinas, Factores de transcripción, Polimorfismo genético |
| Keyword: | Medicine, Hematology, Biochemistry, Hematologic diseases, Transforming growth factor, Cytokines, Transcription factors, Genetic polymorphism |
| Full text: | Texto completo (Ver HTML) |
