Involvement of transforming growth factor beta-1 (TGFβ1) cytokine and FOXP3 transcription factor genetic polymorphisms in hematological malignancies



Título del documento: Involvement of transforming growth factor beta-1 (TGFβ1) cytokine and FOXP3 transcription factor genetic polymorphisms in hematological malignancies
Revista: Brazilian archives of biology and technology
Base de datos: PERIÓDICA
Número de sistema: 000387722
ISSN: 1516-8913
Autores: 1
1
1
2
2
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Instituciones: 1Universidade Estadual de Londrina, Departamento de Ciencias Patologicas, Londrina, Parana. Brasil
2Universidade Estadual de Londrina, Departamento de Patologia, Analises Clínicas e Toxicologicas, Londrina, Parana. Brasil
Año:
Periodo: Jul-Ago
Volumen: 58
Número: 4
Paginación: 553-561
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Hematological malignancies (HM) are a group of neoplastic diseases that arise from hematologic cell lineages. Transforming growth factor beta 1 (TGFβ1) is shown to negatively regulate normal and malignant hematopoiesis and, in immunological context, to promote T cell exhaustion and generation of regulatory T cells, which are shown to be deleterious in cancer, by the induction of transcription factor FOXP3 expression. The present study aimed to evaluate TGFB1 exon-1 rs1800470 and FOXP3 intron-1 rs2232365 polymorphisms in relation to HM susceptibility. DNA was extracted from blood samples of 43 HM patients and 142 neoplasia-free individuals and polymorphisms were analyzed by allelic-specific PCR. Association analysis was assessed by the Odds Ratio (OR) with significance level of 5%. Regarding FOXP3 polymorphism, no significant differences were observed in genotype or allele distribution among the patients and controls. However, there was a positive association between TGFB1 TT genotype and HM susceptibility (OR = 4.07; CI95% = 1.94 - 8.52). In the combined analysis, a positive association was also observed for TGFB1 TT and FOXP3 GG genotypes (OR = 4.00; CI95% = 1.54 - 10.41) in relation to HM susceptibility. Our results indicated promising new markers to be further investigated in hematological malignancies
Disciplinas: Medicina
Palabras clave: Hematología,
Bioquímica,
Enfermedades hematológicas,
Factor de crecimiento transformante,
Citocinas,
Factores de transcripción,
Polimorfismo genético
Keyword: Medicine,
Hematology,
Biochemistry,
Hematologic diseases,
Transforming growth factor,
Cytokines,
Transcription factors,
Genetic polymorphism
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