Hepatoprotective effects of Iranian Hypericum scabrum essential oils against oxidative stress induced by acetaminophen in rats
Document title: Hepatoprotective effects of Iranian Hypericum scabrum essential oils against oxidative stress induced by acetaminophen in rats
Journal: Brazilian archives of biology and technology
Database: PERIÓDICA
System number: 000373456
ISSN: 1516-8913
Authors: 1
2
3
4
4
5
Institutions: 1Islamic Azad University, Faculty of Medicine, Qom. Irán
2Nuclear Science and Technology Research Institute, Nuclear Fuel Cycle Research School, Teherán. Irán
3Isfahan University of Medical Sciences, School of Medicine, Isfahán. Irán
4Islamic Azad University, Faculty of Science, Qom. Irán
5Mazandaran University of Medical Sciences, Azizi Hospital-Juybar, Sari. Irán
Year:
Season: May-Jun
Volumen: 57
Number: 3
Pages: 340-348
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract This studied examined the protective role of Hypericum scabrum oils (100 and 200 mg/kg b.w, i.p) on acetaminophen-induced liver damages in the rat. The hepatic oxidative/antioxidant parameters such as lipid peroxidation (LP), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and ferric reducing ability of plasma (FRAP) were measured 2, 4, 8, 16 and 24h after the treatments confirmed by histopathological consideration. The results indicated that increased levels of hepatic LP and FRAP and SOD activity were reversed in the rats treated with oils. In addition, the depleted GSH were compensated with the oil treatments. The protective effect of the oils was further confirmed by the histophatological examination carried out on liver biopsies. The data pointed out that H. scabrum oil could modulate the hepatic toxicity induced by the APAP through adjusting the oxidative stress/antioxidant parameters and could be of potential candidate for the treatment of acetaminophen induced oxidative stress liver damages
Disciplines: Medicina,
Química
Keyword: Farmacología,
Medicina experimental,
Plantas medicinales,
Aceites esenciales,
Hepatoprotección,
Estrés oxidativo,
Hypericum scabrum
Keyword: Medicine,
Chemistry,
Experimental medicine,
Pharmacology,
Medicinal plants,
Essential oils,
Hepatoprotection,
Oxidative stress,
Hypericum scabrum
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