Revista: | Brazilian archives of biology and technology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000373456 |
ISSN: | 1516-8913 |
Autors: | Dadkhah, Abolfazl1 Fatemi, Faezeh2 Farsani, Mohsen Eslami3 Roshanaei, Kambiz4 Alipour, Mahdi4 Aligolzadeh, Hadi5 |
Institucions: | 1Islamic Azad University, Faculty of Medicine, Qom. Irán 2Nuclear Science and Technology Research Institute, Nuclear Fuel Cycle Research School, Teherán. Irán 3Isfahan University of Medical Sciences, School of Medicine, Isfahán. Irán 4Islamic Azad University, Faculty of Science, Qom. Irán 5Mazandaran University of Medical Sciences, Azizi Hospital-Juybar, Sari. Irán |
Any: | 2014 |
Període: | May-Jun |
Volum: | 57 |
Número: | 3 |
Paginació: | 340-348 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | This studied examined the protective role of Hypericum scabrum oils (100 and 200 mg/kg b.w, i.p) on acetaminophen-induced liver damages in the rat. The hepatic oxidative/antioxidant parameters such as lipid peroxidation (LP), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and ferric reducing ability of plasma (FRAP) were measured 2, 4, 8, 16 and 24h after the treatments confirmed by histopathological consideration. The results indicated that increased levels of hepatic LP and FRAP and SOD activity were reversed in the rats treated with oils. In addition, the depleted GSH were compensated with the oil treatments. The protective effect of the oils was further confirmed by the histophatological examination carried out on liver biopsies. The data pointed out that H. scabrum oil could modulate the hepatic toxicity induced by the APAP through adjusting the oxidative stress/antioxidant parameters and could be of potential candidate for the treatment of acetaminophen induced oxidative stress liver damages |
Disciplines | Medicina, Química |
Paraules clau: | Farmacología, Medicina experimental, Plantas medicinales, Aceites esenciales, Hepatoprotección, Estrés oxidativo, Hypericum scabrum |
Keyword: | Medicine, Chemistry, Experimental medicine, Pharmacology, Medicinal plants, Essential oils, Hepatoprotection, Oxidative stress, Hypericum scabrum |
Text complet: | Texto completo (Ver HTML) |