| Journal: | Brazilian archives of biology and technology |
| Database: | PERIÓDICA |
| System number: | 000392747 |
| ISSN: | 1516-8913 |
| Authors: | Rosa, Damiana Diniz1 Reis, Sandra Aparecida dos1 Siqueira, Nathane Pais1 Goncalves, Reggiani Vilela2 Machado, Alessandra Barbosa Ferreira3 Tafuri, Natalia Filardis1 Leite, Joao Paulo Viana4 Matta, Sergio Luis Pinto da5 Peluzio, Maria do Carmo Gouveia1 |
| Institutions: | 1Universidade Federal de Vicosa, Departamento de Nutricao e Saude, Vicosa, Minas Gerais. Brasil 2Universidade Federal de Vicosa, Departamento de Biologia Animal, Vicosa, Minas Gerais. Brasil 3Universidade Federal de Juiz de Fora, Departamento de Microbiologia, Juiz de Fora, Minas Gerais. Brasil |
| Year: | 2015 |
| Season: | Sep-Oct |
| Volumen: | 58 |
| Number: | 5 |
| Pages: | 731-740 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | The aim of this study was to investigate the effect of the bark extract Bathysa cuspidata on chemically induced preneoplastic colorectal lesions in Wistar rats. Forty male rat s were randomly divided into four groups (n = 10 each): saline (control group, oral administration of saline solution 0.9%); dimethylsulfoxide (DMSO, vehicle control), B200 (treated with 200 mg/kg bark extract of B. cuspidata ), and B400 (treated with 400 m g/kg bark extract of B. cuspidata ). Administration of treatments was carried out by the gavage. The animals received four subcutaneous injections of 1,2 - dimethylhydrazine (DMH, 40 mg/kg) in the initial two weeks of the experiment to induce preneoplastic co lorectal lesions. After 15 weeks, the animals were euthanized and the presence of aberrant crypt foci (ACF), body weight, biochemical analyses, and oxidative stress markers were measured. The extract of B. cuspidata decreased the levels of superoxide dismu tase (SOD), but did not influence the levels of catalase (CAT), malondialdehyde (MDA), nitric oxide or protein carbonyl, compared with the saline group. The animals supplemented with a more concentrated B. cuspidata extract (B400) showed a significant redu ction in the number of ACF in all the portions of the intestinal mucosa. The study demonstrated that the bark extract of B. cuspidata at 400 mg/kg reduced the preneoplastic colorectal lesions in an animal model of colon cancer and that the effect could be dose - dependent |
| Disciplines: | Química, Medicina |
| Keyword: | Bioquímica, Fitoquímica, Medicina experimental, Bathysa cuspidata, Modelos animales, Estrés oxidativo, Lesiones, Propiedades químicas |
| Keyword: | Chemistry, Medicine, Biochemistry, Phytochemistry, Experimental medicine, Bathysa cuspidata, Animal models, Oxidative stress, Lesions, Chemical properties |
| Full text: | Texto completo (Ver PDF) |
