| Journal: | Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas |
| Database: | PERIÓDICA |
| System number: | 000394549 |
| ISSN: | 0717-7917 |
| Authors: | Mamadalieva, Nilufar Z1 Vinciguerra, Vittorio2 Sobeh, Mansour3 Ovidi, Elisa2 Ashour, Mohamed L3 Wink, Michael3 Tiezzi, Antonio2 |
| Institutions: | 1Institute of the Chemistry of Plant Substances AS RUz, Laboratory of the Chemistry of Glycosides, Tashkent. Uzbekistán 2Tuscia University, Department for the Innovation in Biological, Agro-food and Forestal Systems, Viterbo. Italia 3Heidelberg University, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Baden-Wurttemburg. Alemania |
| Year: | 2015 |
| Season: | Nov |
| Volumen: | 14 |
| Number: | 6 |
| Pages: | 442-448 |
| Country: | Chile |
| Language: | Español |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| Spanish abstract | Las especies Phlomis (Phlomis bucharica Regel y P. salicifolia Regel) se han utilizado tradicionalmente por la gente de Uzbekistán como estimulante, tónico, diurético, y en el tratamiento de las úlceras, hemorroides, heridas y problemas ginecológicos. En el presente estudio, hemos caracterizado la composición química de los extractos no polares de P. bucharica y P. salicifolia por GLC-MS de alta resolución y se evaluó su citotoxicidad. Las concentraciones de ácido hexadecanoico en extractos de hexano y cloroformo fueron mayores en P. bucharica que en P. salicifolia. 1,8-cineol, alcanfor, borneol, se detectaron α-terpinol, timol, y acetato de isobornilo en P. bucharica pero no en P. salicifolia. Cerca de 45 componentes fueron identificados en P. bucharica y 40 en P. salicifolia. El extracto de cloroformo a partir de P. bucharica mostró citotoxicidad en células HL-60 y HeLa, con valores de CI 50 de 26,07 y 29,42 µg/ml, respectivamente |
| English abstract | Phlomis species (Phlomis bucharica Regel and P. salicifolia Regel) have been traditionally used by Uzbek people as stimulant, tonic, diuretic, and in the treatment of ulcers, hemorrhoids, wounds and gynecological problems. In the present study, we characterized the chemical composition of non-polar extracts from P. bucharica and P. salicifolia by high resolution GLC-MS and evaluated their cytotoxicity. Concentrations of hexadecanoic acid in hexane and chloroform extracts were higher in P. bucharica than in P. salicifolia. 1,8- Cineol, camphor, borneol, α-terpinol, thymol, and isobornyl acetate were detected in P. bucharica but not in P. salicifolia. About 45 components were identified in P. bucharica and 40 in P. salicifolia. The chloroform extract from P. bucharica showed cytotoxicity in HeLa and HL-60 cells, with IC50 values of 26.07 and 29.42 µg/ml, respectively |
| Disciplines: | Biología, Química |
| Keyword: | Botánica, Fitoquímica, Phlomis bucharica, Phlomis salicifolia, Aceites esenciales, Compuestos volátiles, Citotoxicidad, Plantas medicinales, Uzbekistán |
| Keyword: | Biology, Chemistry, Botany, Phytochemistry, Phlomis bucharica, Phlomis salicifolia, Essential oils, Volatile compounds, Cytotoxicity, Medicinal plants, Uzbekistan |
| Full text: | Texto completo (Ver PDF) |
