| Journal: | Biocell |
| Database: | PERIÓDICA |
| System number: | 000324479 |
| ISSN: | 0327-9545 |
| Authors: | Villalobos, Virginia1 Bonilla, Ernesto2 Castellano, Alan3 Novo, Ernesto1 Caspersen, Ralph4 Giraldoth, Debora1 Medina Leendertz, Shirley4 |
| Institutions: | 1Universidad del Zulia, Facultad Experimental de Ciencias, Maracaibo, Zulia. Venezuela 2Universidad del Zulia, Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Maracaibo, Zulia. Venezuela 3Universidad del Zulia, Instituto de Investigaciones Biológicas, Maracaibo, Zulia. Venezuela 4Instituto Venezolano de Investigaciones Científicas, Centro de Investigaciones Biomédicas, Maracaibo, Zulia. Venezuela |
| Year: | 2009 |
| Season: | Dic |
| Volumen: | 33 |
| Number: | 3 |
| Pages: | 187-197 |
| Country: | Argentina |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The effect of manganese toxicity on the ultrastructure of the olfactory bulb was evaluated. Male albino mice were injected intraperitoneally with MnCl2 (5 mg/Kg/day) five days per week during nine weeks. The control group received NaCl (0.9%). The olfactory bulbs of five mice from each group were processed for transmission electron microscopy after 2, 4, 6 and 9 weeks of manganese treatment. On week 2, some disorganization of the myelin sheaths was observed. After 4 weeks, degenerated neurons with dilated cisternae of rough endoplasmic reticulum and swollen mitochondria appeared. A certain degree of gliosis with a predominance of astrocytes with swollen mitochondria, disorganization of the endomembrane system, dilation of the perinuclear cisternae and irregularly shaped nuclei with abnormal chromatin distribution were observed after 6 weeks. Some glial cells showed disorganization of the Golgi apparatus. On week 9, an increase in the number of astrocytes, whose mitochondrial cristae were partially or totally erased, and a dilation of the rough endoplasmic reticulum were found. Neurons appear degenerated, with swollen mitochondria and a vacuolated, electron dense cytoplasm. These changes seem to indicate that the olfactory bulb is sensitive to the toxic effects of manganese |
| Disciplines: | Medicina, Biología |
| Keyword: | Toxicología, Mamíferos, Manganeso, Bioensayos, Toxicidad, Neurodegeneración, Bulbo olfatorio |
| Keyword: | Medicine, Biology, Toxicology, Mammals, Manganese, Bioassays, Toxicity, Neurodegeneration, Olfactory bulb |
| Full text: | Texto completo (Ver PDF) |
