Journal: | Biocell |
Database: | PERIÓDICA |
System number: | 000321963 |
ISSN: | 0327-9545 |
Authors: | Lee, Chang Seok1 Shin, Yong Jae1 Won, Cheolhee1 Lee, Yun-Song2 Park, Chung-Yu1 Ye, Sang-Kyu1 Chung, Myung-Hee1 |
Institutions: | 1Seoul National University, College of Medicine, Seúl. Corea del Sur 2Sungkyunkwan University, School of Medicine, Suwon. Corea del Sur |
Year: | 2009 |
Season: | Ago |
Volumen: | 33 |
Number: | 2 |
Pages: | 107-114 |
Country: | Argentina |
Language: | Inglés |
Document type: | Artículo |
Approach: | Experimental, aplicado |
English abstract | Cyclooxygenase-2 (COX-2) is a key inflammatory response molecule, and associated with many immune functions of monocytes/macrophages. Particularly, interferon gamma (IFNγ)-induced COX-2 expression appears in inflammatory conditions such as viral infection and autoimmune diseases. Recently, statins have been reported to show variable effects on COX-2 expression, and on their cell and species type dependences. Based on the above description, we compared the effect of simvastatin on IFNγ-induced COX- 2 expression in human monocytes versus murine macrophages. In a result, we found that simvastatin suppresses IFNγ-induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNγ-induced COX-2 expression in murine RAW264.7 macrophages. However, signal transducer and activator of transcription 1/3 (STAT1/3), known as a transcription factor on COX-2 expression, is inactivated by simvastatin in both cells. Our findings showed that simvastatin is likely to suppress IFNγ-induced COX-2 expression by inhibiting STAT1/3 activation in human THP-1 cells, but not in murine RAW264.7 cells. Thus, we concluded that IFNγ-induced COX-2 expression is differently regulated by simvastatin depending on species specific mechanism |
Disciplines: | Biología, Química |
Keyword: | Biología celular, Inmunología, Bioquímica, Simvastatina, Ciclooxigenasa 2, Monocitos, Macrófagos |
Keyword: | Biology, Chemistry, Cell biology, Immunology, Biochemistry, Simvastatin, Cycloxygenase 2, Monocytes, Macrophages |
Full text: | Texto completo (Ver PDF) |