Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells
Título del documento: Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells
Revista: Biocell
Base de datos: PERIÓDICA
Número de sistema: 000321963
ISSN: 0327-9545
Autors: 1
1
1
2
1
1
1
Institucions: 1Seoul National University, College of Medicine, Seúl. Corea del Sur
2Sungkyunkwan University, School of Medicine, Suwon. Corea del Sur
Any:
Període: Ago
Volum: 33
Número: 2
Paginació: 107-114
País: Argentina
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Cyclooxygenase-2 (COX-2) is a key inflammatory response molecule, and associated with many immune functions of monocytes/macrophages. Particularly, interferon gamma (IFNγ)-induced COX-2 expression appears in inflammatory conditions such as viral infection and autoimmune diseases. Recently, statins have been reported to show variable effects on COX-2 expression, and on their cell and species type dependences. Based on the above description, we compared the effect of simvastatin on IFNγ-induced COX- 2 expression in human monocytes versus murine macrophages. In a result, we found that simvastatin suppresses IFNγ-induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNγ-induced COX-2 expression in murine RAW264.7 macrophages. However, signal transducer and activator of transcription 1/3 (STAT1/3), known as a transcription factor on COX-2 expression, is inactivated by simvastatin in both cells. Our findings showed that simvastatin is likely to suppress IFNγ-induced COX-2 expression by inhibiting STAT1/3 activation in human THP-1 cells, but not in murine RAW264.7 cells. Thus, we concluded that IFNγ-induced COX-2 expression is differently regulated by simvastatin depending on species specific mechanism
Disciplines Biología,
Química
Paraules clau: Biología celular,
Inmunología,
Bioquímica,
Simvastatina,
Ciclooxigenasa 2,
Monocitos,
Macrófagos
Keyword: Biology,
Chemistry,
Cell biology,
Immunology,
Biochemistry,
Simvastatin,
Cycloxygenase 2,
Monocytes,
Macrophages
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